The Ion Proton^TM System is the first benchtop sequencing system capable of human-scale genome, exome, or transcriptome sequencing in a few hours—with DNA-to-variants called in a single day.

The system combines semiconductor sequencing technology with natural biochemistry to directly translate chemical information into digital data. By leveraging the exponential improvements in the semiconductor industry (known as Moore’s Law), the Ion Proton^TM Sequencing System provides an unprecedented level of scalability and flexibility to support a broad range of high throughput sequencing applications, ranging from human-scale genome to exome to transcriptome sequencing. The system’s use of the simplest natural sequencing chemistry eliminates the need for expensive optics and complex sequencing chemistries, resulting in a highly affordable sequencing system to own and operate. Real-time, direct, electrical detection of sequencing, combined with the enormous amount of computing power in both the Ion Proton^TM Sequencer and Ion Proton^TM Torrent Server, enables generation of high quality sequencing results from DNA library to variants in a single day.

Fastest high-throughput next-generation sequencing workflow with the fastest sequencing run-times of 2–4 hours on the Ion PI^TM Chip
• Highest number of complete sequencing runs per week, with a simple and automated workflow (when used with the Ion OneTouch^TM 2 System)
• Simple semiconductor sequencing workflows with robust and simple hardware that can be relied upon—no cameras, no optics, and no lasers
• Scalable, high throughput sequencing capabilities, allowing runs for either Ion PI^TM or Ion PII^TM * chips, along with up to 200-base single reads and flexible library options (e.g., fragment gDNA, targeted/exome, RNA)
• Small benchtop footprint and mounting capability (with optional rack) (two Ion Proton^TM systems per rack), to deliver the only benchtop genome center
• Low-cost platform and attractively priced semiconductor chips and reagents for a range of applications
• Proven Ion semiconductor sequencing requires no complex optics and employs natural nucleotides to deliver highly accurate variant detection, uniformity of coverage, and sensitivity to detect low frequency variants
Range of fast and simple library solutions and kits with low-input requirements for a variety of applications, such as genomic sequencing, exome sequencing, sequencing sets of genes, and RNA sequencing
• Complete end-to-end solution from base calls to variants with the Proton^TM Torrent Server and Torrent Suite Software v3.0
•Simple and integrated tools for tertiary data analysis with Ion Reporter^TM Software for DNA variation analysis across single, paired, or trio samples

With the availability of the groundbreaking Ion Proton^TM System, rapid, high throughput sequencing is finally accessible by all laboratories.

• Small genome sequencing
• Amplicon sequencing (16S rRNA sequencing)
• Targeted sequencing
• Whole genome / Exome sequencing